Year: 2012
Type: book-chapter
Abstract: As the worldwide prevalence of type 2 diabetes continues to rise, there is mounting evidence that failure of the cells which make insulin – termed pancreatic beta (or β) cells, play a fundamental role at all stages in the pathogenesis. Beta-cell defects such as loss of the initial (first) phase of insulin secretion and inefficient insulin synthesis are seen years prior to the onset of type 2 diabetes. Later, it is the failure of beta cells to adequately respond to the demand for high insulin requirements that determines the onset of hyperglycaemia leading to the clinical diagnosis of type 2 diabetes. In this chapter, we will discuss the various proposed mechanisms of beta-cell failure in type 2 diabetes and address recent controversies in this field of research.
Authors: Jenny E. Gunton, Christian M. Girgis
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1597128883