Work

Genetic polymorphism of KIR2DL4 ( CD158d ), a putative NK cell receptor for HLA ‐G, does not influence susceptibility to asthma

Year: 2013

Type: article

Abstract: Human leukocyte antigen (HLA)-G is upregulated on the bronchial epithelium of asthma patients and genetic polymorphism affecting expression of HLA-G has been reported to influence susceptibility to asthma. As the NK cell receptor KIR2DL4 has been reported to induce interferon gamma (IFNγ) secretion when ligated with HLA-G, we postulated that the 9A/10A genetic polymorphism of KIR2DL4 which influences receptor structure may influence susceptibility to asthma. KIR2DL4 genotypes were determined in two cohorts of children (n = 219 and n = 1356) in whom total serum IgE, allergen-specific IgE, atopy, bronchial reactivity and asthma symptoms had been studied between birth and 14 years. No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence on susceptibility to asthma.

Source: Tissue Antigens

DOI: 10.1111/tan.12185

Authors: M. E. L. Le Page, J. P. Goodridge, G. Zhang, P. G. Holt, P. Sly, C. S. Witt

Institutions: The University of Western Australia, Fred Hutch Cancer Center, The University of Queensland, The Kids Research Institute Australia, Queensland Children’s Medical Research Institute, Royal Perth Hospital

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1597201736

FWCI: 0.621

Cites: 25

Cited by: 5

Related to: 10