Work

Direct inhibition of tyrosine hydroxylase activity by catechol estrogens.

Year: 1978

Type: article

Abstract: Catechol estrogens, the 2-hydroxylated metabolites of estrogens, recently shown to be formed in brain, inhibit tyrosine hydroxylase, the enzyme that catalyzes the pivotal step in the biosynthesis of the neurotransmitters dopamine and norepinephrine. The nature of the inhibition is by competition with the pterin cofactor and thus resembles feedback inhibition of the enzyme by catecholamines.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(17)34622-7

Authors: T. Lloyd, J. Weisz

Institutions: Pennsylvania State University, Penn State Milton S. Hershey Medical Center

Language: English

Topic: Estrogen and related hormone effects

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430