Work

PCOS and obesity: insulin resistance might be a common etiology for the development of type I endometrial carcinoma.

Year: 2014

Type: article

Abstract: Endometrial cancer (EC) is the most common gynecological malignancy in women and is the leading cause of cancer-related deaths worldwide. Estrogenic stimulation significantly increases endometrial cell proliferation, and both insulin resistance and hyperinsulinemia are associated with the development of EC in women. It has long been known that insulin resistance occurs in women with polycystic ovary syndrome (PCOS) and/or obesity, but one important unanswered question is whether the insulin resistance associated with PCOS and obesity is part of the etiology of the initiation and development of EC. Therefore, research efforts to understand the common and specific underlying endometrial responses to insulin resistance in women with PCOS and obesity could provide further therapeutic options for early endometrial carcinoma.

Source: Europe PMC (PubMed Central)

Authors: Xin Li, Ruijin Shao

Institutions: Fudan University, Obstetrics and Gynecology Hospital of Fudan University, University of Gothenburg

Language: English

Topic: Endometrial and Cervical Cancer Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1599235106

FWCI: 5.09

Cites: 54

Cited by: 33

Related to: 10