Work

Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects

Year: 1998

Type: article

Abstract: Polysomnography was performed on eight healthy men with trazodone hydrochloride, imipramine and placebo. Trazodone hydrochloride increased slow wave sleep significantly. Imipramine prolonged rapid eye movement (REM) latency and decreased the percentage of REM sleep significantly. Trazodone decreased stages 1 and 2 sleep, while imipramine increased it. These findings suggest that the antidepressive effect of trazodone might be different from that of imipramine with the suppression of REM sleep.

Source: Psychiatry and Clinical Neurosciences

DOI: 10.1046/j.1440-1819.1998.00403.x

Authors: HIROSHI YAMADERA, SHUICHI NAKAMURA, HIDEAKI SUZUKI, SHUNKICHI ENDO

Institution: Nippon Medical School

Language: English

Topic: Sleep and Wakefulness Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Mental Health