Work

Promoter Methylation in Head and Neck Tumorigenesis

Year: 2012

Type: book-chapter

Abstract: In addition to genetic alterations of gains and losses, epigenetic events of promoter methylation appear to further undermine a destabilized genomic repertoire in squamous head and neck carcinoma (HNSCC). This chapter provides an overview of frequently methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck tumorigenesis.

Source: Methods in molecular biology

DOI: 10.1007/978-1-61779-612-8_11

Authors: Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, Maria J. Worsham

Institution: Henry Ford Hospital

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Dental and Craniofacial Research