Fibroblast growth factor receptor 1 signaling in the early development of the midbrain-hindbrain and pharyngeal region
Year: 2005
Type: dissertation
Abstract: Organizing centers commonly regulate development of an embryo.One such center that regulates development of the neural tube is the isthmic organizer, which is located at the boundary between the midbrain and rhombomere 1 of the hindbrain.Although a lot is known on the molecular properties of the isthmic organizer, very little is known about the mechanisms responsible for the maintenance and coherence of this signaling center. Fgfr1 null mutants die early during gastrulation.To analyze the role of the Fgfr1 in the midbrain-hindbrain and midbrain we generated Fgfr1 midbrain-hindbrain and midbrain specific mutants.Tissue specific
Source: Työväentutkimus Vuosikirja
Author: Ras Trokovic
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1602199084