Year: 2008
Type: article
Study design: Observational Study
Abstract: Little is known about what effector populations are associated with the control of human herpesvirus 8 (HHV-8) infection in vivo. We compared T lymphocyte subsets among HIV-HHV-8+ and HIV-HHV-8- infected human individuals. alphabeta+ T cells from HHV-8-infected individuals displayed a significantly higher percentage of differentiated effector cells among both CD4+ and CD8+ T cell subsets. HHV-8 infection was associated with significant expansion of gammadelta+ Vdelta1 T cells expressing a differentiated effector cell phenotype in peripheral blood. In vitro stimulation of PBMC from HHV-8-infected individuals with either infectious viral particles or different HHV-8 viral proteins resulted in gammadelta Vdelta1 T cell activation. In addition, gammadelta Vdelta1 T cells displayed a strong reactivity against HHV-8-infected cell lines and prevented the release of infectious viral particles following the induction of lyric replication. These data indicate that gammadelta T cells play a role in both innate and adaptive T cell responses against HHV-8 in immunocompetent individuals.
Source: The Journal of Immunology
Institutions: Fred Hutch Cancer Center, University of Washington
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G173189196, HHV-8 Transmission Among Men Who Have Sex with Men, G2703340248, G2767126187, Clinical Epidemiology and Pathogenesis of Asymptomatic HSV, G340326014, Cytotoxic T-Cell Responses to HSV: HIV-Infected Persons, Oral-Pharyngeal HHV-8 Infection, Transmission and Acquisition of KSHV, G8399419701, G9000057394, G9000194059, University of Washington/Fred Hutch Center for AIDS Research
OpenAlex ID: W1603073023