Effects of a single low-dose acetaminophen on body temperature and running performance in the heat: a pilot project.
Year: 2013
Type: article
Study design: Clinical Trial
Abstract: PURPOSE: To examine the effects of a single low-dose (500 mg) acetaminophen on body temperature and running performance in the heat (30 °C). METHODS: This is a randomized, cross-over pilot study performed in a climatic chamber at the Department of Sport Science of the University of Innsbruck. Seven male sport students (age, 25.9 ± 2.3 years; VO2max, 67.3 ± 7.1 mL/min/kg) participated in the study. Each participant performed two prolonged exercise tests at a constant intensity on a treadmill at a temperature of 30 °C at an individual intensity corresponding to 70 % VO2max. Two hours before exercising participants were randomly assigned to receive acetaminophen (500 mg) or placebo and performed the same test 2 weeks later with reverse pre-treatment. RESULTS: After 20 min of running in the heat core temperature increase was less under acetaminophen (P = 0.004) and heart rates were higher (P = 0.02) compared to placebo. At the end of exercise neither running time nor body temperature nor ratings of perceived exertion differed between groups. CONCLUSION: Although the increase in core temperature was slightly reduced by acetaminophen after 20 minutes of running in the heat running performance remained unaffected after pre-treatment with a single low-dose of acetaminophen.
Source: Europe PMC (PubMed Central)
Authors: Martin Burtscher, Hannes Gatterer, Marc Philippe, Philipp Krüsmann, Stefanie Kernbeiss, Veronica Frontull, Philipp Kofler
Institutions: Innsbruck Medical University, Universität Innsbruck
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1603151414