Screening panels for monoclonal gammopathies: time to change.
Year: 2009
Type: article
Abstract: The introduction of quantitative assays for serum free light chains (FLC) has changed the approach to screening for monoclonal gammopathies. Recent guidelines from the International Myeloma Working Group have recommended the use of serum protein electrophoresis (SPEP), immunofixation electrophoresis (IFE) and FLC as the screening panel unless primary amyloidosis (AL) is suspected. If screening for AL, then urine IFE should also be performed. We discuss the background for these recommendations as well as data showing that SPEP and FLC alone may provide a simplified screening panel for detecting multiple myeloma (MM) and Waldenström's macroglobulinaemia (WM) with little loss of diagnostic sensitivity. If AL is suspected, we support the recommendation to include serum and urine IFE. The selective use of serum and urine IFE requires that clinical judgment be integral to ordering screening panels for detection of monoclonal gammopathies.
Source: PubMed
Author: Jerry A Katzmann
Institution: Mayo Clinic
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1603966580