Work

TLRs control hematopoiesis during infection

Year: 2013

Type: review

Abstract: Recent research has shown that (i) Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to proliferate and differentiate along the myeloid lineage in vitro, and (ii) direct TLR-mediated stimulation of HSPCs also promotes macrophage differentiation in vivo following infection. These new insights demonstrate that TLR signaling in HSPCs, in addition to other TLR-dependent mechanisms, can contribute to HSPC expansion and myeloid differentiation after infection. Evidence is, therefore, mounting that direct TLR-induced programming of hematopoiesis plays a key role in host defense by rapidly replenishing the innate immune system with the cells needed to deal with pathogens.

Source: European Journal of Immunology

DOI: 10.1002/eji.201343833

Authors: Alberto Yáñez, Helen S. Goodridge, Daniel Gozalbo, M. Luisa Gil

Institutions: Cedars-Sinai Medical Center, Universitat de València

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministerio de Economía y Competitividad, National Institute of Allergy and Infectious Diseases