Work

Preclinical Mouse Models of Human Prostate Cancer and Their Utility in Drug Discovery

Year: 2010

Type: article

Abstract: In vivo animal experiments are essential to current prostate cancer research, and are particularly critical to studying interactions between tumor cells and their microenvironment. Numerous pre-clinical animal models of prostate cancer are currently available, including transgenic mouse models and human prostate cancer xenograft mouse models. In contrast to transgenic mouse models producing more heterogeneous cohorts of tumors, xenograft mouse models provide more controlled approaches. This unit describes the detailed procedures necessary to establish several distinct pre-clinical mouse models of human prostate cancer, including an orthotopic prostate xenograft model, an orthotopic bone metastasis model, an experimental metastasis model of intra-cardiac injection, and a vossicle model of tumor-bone interaction.

Source: Current Protocols in Pharmacology

DOI: 10.1002/0471141755.ph1415s51

Authors: Serk In Park, Sun Jin Kim, Laurie K. McCauley, Gary E. Gallick

Institutions: University of Michigan, The University of Texas MD Anderson Cancer Center, Michigan Medicine

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Bristol-Myers Squibb, National Cancer Institute