Testis Factors That May Regulate Gene Expression: Evidence From a Patient With Kartagener's Syndrome
Year: 1995
Type: article
Study design: Case Report
Abstract: Patients with Kartagener's syndrome characteristically have immotile cilia and flagella. Ultrastructural analysis of the efferent ducts of the patient described in this report revealed that the cilia totally lacked dynein arms. Based on clinical findings his respiratory cilia also were not functional. In contrast, this patient's spermatozoa were motile and displayed normal ultrastructure, including dynein arms. This suggests that two genes exist that code for slightly different proteins with analogous functions; one of these genes functions in somatic tissue and the other in the male germ tissue. Differential gene expression in somatic and male germ tissue may be related to the syncytial nature of male germ cells, low scrotal temperature, or haploid gene expression.
Source: Journal of Andrology
Authors: DAVID M. PHILLIPS, WILLIAM W. JOW, MARK GOLDSTEIN
Institutions: Population Council, Cornell University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1606774023