Work

Studies on Squalene Epoxidase of Rat Liver

Year: 1970

Type: article

Abstract: Rat liver microsomes previously heated to 50" for 5 mm accumulate 2,3-oxidosqualene on incubation with squalene.Squalene epoxidase activity can be assayed either with squalene and heated microsomes or with lO,ll-dihydrosqualene and intact microsomes.In common with other monooxygenases, the epoxidase requires TPNH and molecular oxygen.Both a soluble fraction of rat liver and microsomes are necessary for enzyme activity.Carbon monoxide or potassium cyanide fall to inhibit squalene epoxidation.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(19)77144-0

Authors: Shozo Yamamoto, Konrad Bloch

Institution: Harvard University

Language: English

Topic: Plant biochemistry and biosynthesis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W1606948338

FWCI: 2.288

Cites: 18

Cited by: 163

Related to: 10