The long QT syndrome.
Year: 2002
Type: article
Abstract: The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the primary cardiac arrhythmias or cardiac ion channelopathies. The study of inherited LQTS has provided enormous insight into the molecular basis of cardiac electrophysiology and arrhythmogenesis in general. Drug induced LQTS is the most common cause of acquired LQTS, and is a pressing public health issue. Considerable attention has been focussed on this form of LQTS following the withdrawal from the USA market of a number of prescription medications, including terfenedine in 2000 and cisapride in 2001. This review will discuss both forms, but with more emphasis on inherited LQTS.
Source: PubMed
Author: G Michael Vincent
Institutions: University of Utah, LDS Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1607094917