The frontopolar cortex and human cognition: Evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex
Year: 2000
Type: article
Abstract: Numerous brain lesion and functional neuroimaging studies have suggested that the dorsolateral and frontopolar prefrontal regions are involved in complex cognitive processes subserving thought and memory. However, previously proposed functional subdivisions of prefrontal function have concentrated predominantly on posterior prefrontal cortex, including the dorsolateral, ventral, and medial regions. Far less consideration has been given to characterizing the psychological processes mediated by the frontopolar cortex. Here we review published neuroimaging studies of reasoning and episodic memory, two domains in which the frontopolar cortex has been frequently activated. The results suggest that dorsolateral prefrontal cortex is involved when externally generated information is being evaluated, whereas the frontopolar cortex becomes recruited when internally generated information needs to be evaluated. A hierarchical model of prefrontal function is proposed in which dorsolateral and frontopolar regions are serially recruited as a reasoning or memory task requires evaluation of internally generated information.
Source: Psychobiology
DOI: 10.3758/bf03331976
Authors: Kalina Christoff, John D. E. Gabrieli
Institution: Stanford University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1607685652