Abnormal interactions between context, memory structure, and mood in schizophrenia: An ERP investigation
Year: 2014
Type: article
Abstract: This study used event-related potentials to examine interactions between mood, sentence context, and semantic memory structure in schizophrenia. Seventeen male chronic schizophrenia and 15 healthy control subjects read sentence pairs after positive, negative, or neutral mood induction. Sentences ended with expected words (EW), within-category violations (WCV), or between-category violations (BCV). Across all moods, patients showed sensitivity to context indexed by reduced N400 to EW relative to both WCV and BCV. However, they did not show sensitivity to the semantic memory structure. N400 abnormalities were particularly enhanced under a negative mood in schizophrenia. These findings suggest abnormal interactions between mood, context processing, and connections within semantic memory in schizophrenia, and a specific role of negative mood in modulating semantic processes in this disease.
Source: Psychophysiology
DOI: 10.1111/psyp.12289
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Genetic Determinants of Schizophrenia Intermediate Phenotypes, Semantic knowledge and its underlying structures in schizophrenia-an fMRI study, G5520759767, G6319511350, Language Systems in Schizophrenia: Behavioral & ERP Data, G6741269357, Estudos electrofisiológicos do processamento auditivo afectivo na esquizofrenia e sua relação com processos de auto-monitorização: um contributo para a compreensão das alucinações auditivas?, Neurophysiological Studies of Schizophrenia, G7434745637
OpenAlex ID: W1607895943