Gene expression analysis of Flrt1, Flrt2 and Flrt3 in the murine midface during early embryogenesis
Year: 2009
Type: dissertation
Abstract: The Fibronectin leucine-rich transmembrane (Flrt) gene family has been implicated in\nFGF signaling, which is crucial for coordinating craniofacial morphogenesis and epithelial mesenchymal interactions (EMI). The gene expression patterns of Flrt1, Flrt2 and Flrt3 were analyzed during critical stages of murine midfacial development from 9.5-15.5 dpc. Flrt2 and Flrt3 were observed to have unique expression patterns in the midface, whereas Flrt1 did not. From 10.5-12.5dpc, Flrt2 was expressed in the mesenchyme of the medial nasal process(MNP). Flrt3 was expressed in the mesenchyme of the lateral nasal process (LNP) and MNP. From 13.5-15.5dpc, Flrt2 was expressed in the oral ectomesenchyme of the palatal shelves, whereas Flrt3 was expressed in the medial edge and oral epithelium. Both Flrt2 and Flrt3 were expressed in different sites of the developing tooth buds and hair follicles. This suggests that Flrt2 and Flrt3\nhave unique roles during craniofacial morphogenesis, whereas Flrt1 may have a more\ngeneralized role.
Source: TSpace (University of Toronto)
Author: Karen Clare Chung
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1608348663