Work

The impact of fibroblast growth factor-23 on the cardiovascular system in chronic kidney disease

Year: 2015

Type: editorial

Abstract: Chronic kidney disease is associated with an accelerated risk of cardiovascular (CV) mortality. Seminal work over the last decade has identified abnormal bone metabolism as an important modulator of the increased CV burden in this cohort. In particular, FGF23, a phosphaturic hormone with serum levels found to be markedly elevated in chronic kidney disease, is independently associated with increased risks of all-cause mortality and CV events. This editorial will discuss the proposed mechanisms linking FGF23 to CV disease in chronic kidney disease, namely, direct cardiac myocyte toxicity, endothelial dysfunction and vascular calcification.

Source: Expert Review of Endocrinology & Metabolism

DOI: 10.1586/17446651.2015.1079124

Authors: Gavin Lee, Rathika Krishnasamy, Carmel M Hawley, David W Johnson

Institutions: Princess Alexandra Hospital, The University of Queensland, Translational Research Institute

Language: English

Topic: Parathyroid Disorders and Treatments

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1609377807

Cites: 30

Cited by: 3

Related to: 10