Year: 2012
Type: article
Abstract: A b s t r a c t Dodonaea viscosa (L.) Jaeq (Sapindaceae) is used in traditional medicine for the treatment of hemorrhoids, ulcer, and pains of hepatic or stomach origin. The current study was designed to investigate the phytochemical constituents of the plant and evaluate its activity against liver fibrosis induced by carbon tetrachloride (CCl4) in rats. The phytochemical analysis has afforded one flavanone; 5,7-dihydroxy flavanone (pinocembrin) (1) and eight flavones. The compounds were isolated and elucidated as; 5,7-dihydroxy-3,6,4'-trimethoxyflavone (santin) (2), 5,7,4'-trihydroxy-3-methoxy flavone (kaempferol 3-O-methyl ether) (3), 3,4',5-trihydroxy-7-methoxy flavone (kaempferol 7-O-methyl ether) (4), 3',4',5,7-tetrahydroxy-3-methoxy-flavone (quercetin 3'-O-methyl ether) (5), 3,3',4',5,7-pentahydroxyflavone (quercetin) (6), 5,7,4'-trihydroxy-3,6-dimethoxy flavone (7), 5,7-dihydroxy 3,6,3',4'-tetramethoxy flavone (8), and isorhamnetin-3-O-robinobioside (9).. In vitro screening of ethanol extract, fractions of toluene and ethyl acetate, the flavanone and major flavone compounds as antioxidants was carried out. In addition, D. viscosa ethanol extract and two fractions were examined in vivo against liver fibrosis induced by CCl4 in rats. The evaluation was done through measuring hepatic oxidative stress markers; malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD). The work was
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1611266410