Work

Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression.

Year: 2005

Type: article

Abstract: Heritable differences in transcribed RNA levels can be mapped as quantitative trait loci (QTLs). Transcribed RNA levels are often measured by hybridization to microarrays of oligonucleotide probes, in which each transcript is represented by multiple probes. The use of recombinant inbred lines allows an estimate of the heritability of expression measured by individual probes. This heritability varies greatly. We have tested heritability-weighted averages to define expression of a transcript and found that these allow detection of more QTLs than previously described methods.

Source: Genome biology

DOI: 10.1186/gb-2005-6-3-r27

Authors: Kenneth F Manly, Jintao Wang, Robert W Williams

Institutions: University of Tennessee Health Science Center, University at Buffalo, State University of New York

Language: English

Topic: Genetic Mapping and Diversity in Plants and Animals

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Zero hunger

Open Access status: gold

Estimated APC paid: $5,490