Year: 2005
Type: article
Study design: Observational Study
Abstract: We conducted linkage analysis of 80 candidate genes in 201 brother pairs affected with prostatic adenocarcinoma. Markers representing two adjacent candidate genes on chromosome 3p, CDC25A and FHIT, showed suggestive evidence for linkage with single-point identity-by-descent allele-sharing statistics. Fine-structure multipoint linkage analysis yielded a maximum LOD score of 3.17 (P = 0.00007) at D3S1234 within FHIT intron 5. For a subgroup of 38 families in which three or more affected brothers were reported, the LOD score was 3.83 (P = 0.00001). Further analysis reported herein suggested a recessive mode of inheritance. Association testing of 16 single nucleotide polymorphisms (SNP) spanning a 381-kb interval surrounding D3S1234 in 202 cases of European descent with 143 matched, unrelated controls revealed significant evidence for association between case status and the A allele of single nucleotide polymorphism rs760317, located within intron 5 of FHIT (Pearson's chi(2) = 8.54, df = 1, P = 0.0035). Our results strongly suggest involvement of germline variations of FHIT in prostate cancer risk.
Source: Cancer Research
Authors: Garry P. Larson, Yan Ding, Li S-C. Cheng, Cathryn Lundberg, Virgil Gagalang, Guillermo Rivas, Louis Geller, Jeffrey Weitzel, Deborah MacDonald, John Archambeau, Jerry Slater, Donna Neuberg, Mary B. Daly, Irene Angel, Al B. Benson, Kimberly Smith, John M. Kirkwood, Peter J. O'Dwyer, Barbara Raskay, Rebecca Sutphen, Rosalind Drew, James A. Stewart, Jae Werndli, David Johnson, John C. Ruckdeschel, Robert C. Elston, Theodore G. Krontiris
Institutions: Beckman Research Institute, City Of Hope National Medical Center, Loma Linda University Medical Center, Harvard University, Dana-Farber Cancer Institute, Fox Chase Cancer Center, Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, UPMC Hillman Cancer Center, University of Pennsylvania, University of South Florida, Moffitt Cancer Center, University of Wisconsin–Madison, University of Wisconsin Carbone Cancer Center, Vanderbilt University, Vanderbilt-Ingram Cancer Center, The Barbara Ann Karmanos Cancer Institute, MetroHealth, MetroHealth Medical Center, Case Western Reserve University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1615411985