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Growth hormone–STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism

Year: 2011

Type: article

Abstract: The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.

Source: Annals of the New York Academy of Sciences

DOI: 10.1111/j.1749-6632.2011.06100.x

Authors: Myunggi Baik, Ji Hoon Yu, Lothar Hennighausen

Institutions: Chonnam National University, National Institutes of Health

Language: English

Topic: Growth Hormone and Insulin-like Growth Factors

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health