Comparison of Some Urinary Biomarkers of Acute Kidney Injury in Term New Born with and without Asphyxia
Year: 2014
Type: article
Study design: Observational Study
Abstract: Background: Acute kidney injury (AKI) is a frequent clinical condition in neonatal intensive care unit (NICU). Urinary biomarkers can diagnose AKI within hours of an insult that has been discovered. The discovery of biomarkers for AKI that might enable early recognition and clinical intervention to limit renal injury. Objective: Was to evaluate urinary levels of cystatin C, Neutrophil gelatinase-associated lipocalin (NGAL) and IL -18 as early predictive biomarkers of acute kidney injury in term asphyxiated newborn. Patients and Methods: The study included 30 full terms newborn with asphyxia in the first 48 hours of delivery. They were selected from the NICU of Al -Zahraa hospital, Al-Azher University. Also the study included 30 healthy newborn ages and sex matched as a control group. Arterial blood gases (ABG), serum creatinine, urinary cystatin C, (uNGAL) and uIL- 18 were assessed among studied groups. Results: There was a significant increase in the serum creatinine level in the newborn with asphyxia than the control group, but both were in the normal reference range. There was a high significant decrease in pH and o2 saturation in term asphyxiated newborn than the control group. Asphyxiated neonates had significantly higher uCysC, uNGAL and uIL-18 compared to the controls. ucystatin C 100.00% sensitive and specific for prediction of AKI followed by IL-18 100.00% specific, 80.00% sensitivity and NGAL, 93.33% sensitive, 93.33% specific while sCr 46.7 % sensitive, 93.3% specific. Conclusion: uCysC, uNGAL and uIL-18 are specific and sensitive biomarkers for early AKI diagnosis in term asphyxiated newborn: urinary CysC, NGAL and IL18 have a significant predictive value for the identification of AKI in the newborn with asphyxia as compared to SCr.
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W161892878