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Cutting Edge: Association with IκB Kinase β Regulates the Subcellular Localization of Homer3

Year: 2010
Type: article
Abstract: The signaling and adaptor protein Homer3 plays a role in controlling immune homeostasis and self-reactivity. Homer3 is recruited to the immune synapse (IS) following TCR ligation, although the mechanisms regulating this subcellular localization are unknown. We show that Homer3 specifically associates with a novel ubiquitin-like domain in the IkappaB kinase (IKK) beta subunit of the IKK complex. Homer3 associates with IKKbeta in T cells and colocalizes with the IKK complex at the IS. However, Homer3 is not required for IKK activation, as NF-kappaB signaling is intact in Homer3-deficient T cells. Instead, the IKK complex recruits Homer3 to the IS following TCR engagement, and we present evidence that this association regulates actin dynamics in T cells. These findings identify a novel interaction between two major signaling proteins and reveal an unexpected NF-kappaB-independent function for the IKK complex in regulating the subcellular localization of Homer3.
DOI: 10.4049/jimmunol.0903488
Authors: Gayatri Yatherajam, Pinaki P Banerjee, Kelly A McCorkell, Laura A Solt, Eric P Hanson, Lisa A Madge, Shin Kang, Paul F Worley, Jordan S Orange, Michael J May
Language: English
Subfield: Cancer Research
Open Access status: green
Awards: G121837565, G1770487472, G2033312123, G2134434554, G2137198713, G356938070, G388580163, G4424250656, G44716879, G5429867144, G674841539, Directing Function at the Natural Killer Cell Secretory Immunological Synapse, Non-Canonical NF-kappaB Signaling In Endothelial Cells
OpenAlex ID: W1620977295
FWCI: 0.181
Cites: 18
Cited by: 8
Related to: 10