Work

Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle

Year: 2015

Type: article

Abstract: ABSTRACT Exercise training enhances physical performance and confers health benefits, largely through adaptations in skeletal muscle. Mitochondrial adaptation, encompassing coordinated improvements in quantity (content) and quality (structure and function), is increasingly recognized as a key factor in the beneficial outcomes of exercise training. Exercise training has long been known to promote mitochondrial biogenesis, but recent work has demonstrated that it has a profound impact on mitochondrial dynamics (fusion and fission) and clearance (mitophagy), as well. In this review, we discuss the various mechanisms through which exercise training promotes mitochondrial quantity and quality in skeletal muscle.—Drake, J. C., Wilson, R. J., Yan, Z. Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle. FASEB J. 30, 13‐22 (2016). www.fasebj.org

Source: The FASEB Journal

DOI: 10.1096/fj.15-276337

Authors: Joshua C. Drake, Rebecca J. Wilson, Zhen Yan

Institution: University of Virginia

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases