Transfusion of blood stored for longer periods of time does not alter the reactive hyperemia index in healthy volunteers
Year: 2012
Type: article
Abstract: The purpose of this study is to investigate the effects of transfusing human packed red blood cells (PRBC) after prolonged storage, as compared to short storage. Retrospective data suggest that transfusion of PRBC stored for over 2 weeks is associated with increased mortality and morbidity. During storage, PRBC progressively release hemoglobin, which avidly binds nitric oxide (NO). We hypothesized that the NO-mediated hyperemic response following ischemia would be reduced after transfusion of PRBC stored for 40 days.
Source: Critical Care
DOI: 10.1186/cc11055
Authors: A Coppadoro, L Berra, B Yu, C Lei, E Spagnolli, AU Steinbicker, KD Bloch, T Lin, HS Warren, FY Sammy, BO Fernandez, M Feelisch, WH Dzik, CP Stowell, WM Zapol
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
OpenAlex ID: W1627054669