Work

Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients

Year: 2011

Type: dissertation

Abstract: Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ABCB1. Genetic variability in the above genes may contribute to differences in EFV plasma concentrations which affect the levels of viral suppression as well as development of side effects in patients. The aim of this project was to evaluate the effects of the different genetic polymorphisms on EFV plasma concentration levels in HIV/AIDS patients receiving first-line antiretroviral treatment (ART) containing EFV.

Source: Open University of Cape Town (University of Cape Town)

Author: Marelize Swart

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Research Foundation, Poliomyelitis Research Foundation, University of Cape Town, Medical Research Council

OpenAlex ID: W1629368540

Cites: 163

Cited by:

Related to: 10