Year: 1996
Type: dissertation
Abstract: Clinical aspects of GH therapy in adults ChapterChapter Chapter Chapter Nawoord associated with changes in body composition (1.5.1.),impaired physical performance (1.5.2.), reduction in bone mineral content (1.5.3.), disorders in lipid metabolism, impaired cardiac function with increased cardiovascular morbidity and mortality (1.5.4.), and decreased psychological well-being (1.5.5.).Clinical aspects of GH therapy in adults 1.5.2. Physical performancePatients with GHD have lowered muscle size and strength.compared to normal controls (67,135).When GH replacement therapy is stopped in children, when adult height has been achieved, muscle size and strength decrease within several months (136).Initiation of GH replacement therapy in GHD adults causes an increase in lean body mass, 50% of which consists of muscle, while also exercise performance improves (137,138).When studied in a metabolic ward situation an increase in whole body protein turnover, protein synthesis and breakdown were found resulting in a positive nitrogen balance (32,61).After a substantial increase of total body protein mass a new steady state will be reached.
Author: Nick K. Valk
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Eli Lilly and Company
OpenAlex ID: W1630319789