Year: 2014
Type: dissertation
Abstract: Introduction: From year 2007. in vitro and in vivo studies have suggested a role of undercarboxylated osteocalcin (ucOC) in glucose and energy metabolism. ----- Aims: The aim of the study was to investigate the relationship of ucOC level and blood glucose (BG) control in newly diagnosed type 2 diabetes and its change with BG control improvement. ----- Subjects and methods: Fifty seven newly diagnosed type 2 diabetic patients had a consultation about life style changes on visit 1, no BG regulation medication was prescribed. The final visit (2) was three months later. Samples for parameters of BG metabolism and bone turnover were collected on visit 1 and 2. ----- Results: Forty seven patients completed the study. Thirty two (56%) patients reached the target HbA1c (≤7%). No correlation of ucOC and HbA1c and FBG was observed. Median HbA1c and FBG changed significantly (8.0 to 6.5%; 9.0 to 7.0 mmol/L resp.; Wilcoxon signed rank test p<0.001), ucOC was slightly but not significantly lower (2.0 to 1.4 mcg/L; p=0.465). No correlation between differences in HbA1c and ucOC between Visits 1 and 2 was revealed. There was a significant change in HOMA%B but not HOMA IR, not correlated to ucOC. ----- Conclusion: This study failed to prove the relationship between blood glucose regulation and ucOC level. However, it does not exclude it, so further research is needed. The fact that as much as 56% patients achieved the target HbA1c with no medication, challenges most BG control guidelines.
Author: Berisha-Muharremi, Venera
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W163218510