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Eukaryotic circadian systems: cycles in common

Year: 1999
Type: review
Abstract: Common regulatory patterns can now be discerned among eukaryotic circadian systems, extending from fungi through to mammals. Complexes of two distinct PAS domain-containing transcription factors play positive roles in clock-associated feedback loops by turning on classic clock proteins such as FRQ, PER and TIM. These in turn appear to act as negative elements, interfering with their own activation and thus giving rise to an oscillatory negative feedback loop. Post-transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature.
DOI: 10.1046/j.1365-2443.1999.00239.x
Language: English
Open Access status: bronze
Funders: National Science Foundation, Dartmouth College, National Institutes of Health, Norris Cotton Cancer Center, National Institute of Mental Health, National Institute of General Medical Sciences
Awards: G1628237272, G4008756567, G4398246120, Identification and Analysis of Clock Controlled Genes, Genetics and Molecular Biology of Temporal Control in a Simple Eukaryote, IDENTIFICATION AND ANALYSIS OF CLOCK CONTROLLED GENES
OpenAlex ID: W1633702056
FWCI: 0.494
Cites: 98
Cited by: 86
Related to: 10