Work

Mechanism of NLRP3 inflammasome activation

Year: 2014

Type: review

Abstract: Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1-dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. The NLRP3 inflammasome is the most thoroughly studied of the inflammasome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists. This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.

Source: Annals of the New York Academy of Sciences

DOI: 10.1111/nyas.12458

Authors: Fayyaz S. Sutterwala, Stefanie Haasken, Suzanne L. Cassel

Institutions: University of Iowa, Iowa City VA Medical Center

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Asthma and Allergy Foundation of America, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Environmental Health Sciences