Work

Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus

Year: 1990

Type: article

Abstract: We have carefully examined the frequency of guanidine-resistant revertants in six different clonal pools of guanidine-dependent mutants of type 1 poliovirus. The mutation frequency was (6.5 +/- 6.3) x 10(-4) (with all amino acid substitutions occurring at position 227). The minimal corrected base substitution frequency per single nucleotide site in the codon for amino acid 227 was (2.1 +/- 1.9) x 10(-4).

Source: Journal of Virology

DOI: 10.1128/jvi.64.2.664-671.1990

Authors: J C de la Torre, E Wimmer, J J Holland

Institution: University of California San Diego

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases