The Pathogenesis of Duodenal Ulcer Disease in the Pantothenate-deficient Rat.
Year: 1963
Type: article
Abstract: A relationship between pantothenic acid and the morphological integrity of the bowel has been demonstrated by a number of investigators.1"l'- " '" Among these, the consistent findings of Zucker1 and our own observations of chronic duodenal ulceration in pantothenate deficiency ' have prompted us to search for antecedent lesions which, though less obvious than ulceration, might prove to be more specific and informative. And since we have been aware that the phenomenon of ulceration is readily demonstrable only in certain strains, it seemed of interest to discover what happened in pantothenate deficiency to the duodenal mucosa of a strain where ulceration rarely occurs. Young adult rats were used since they have been shown to be more prone to ulcer development than weanlings." MATERIALS AND METHODS Rats of both sexes (Zucker 9B and 13C strains) ' were put on experiment at 30 weeks of age. They were divided into 10 groups of 12 animals. Each group of 12 consisted of five experimental and one control animal from each of the two strains. The schedule for
Source: PubMed Central
Author: J SERONDE
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1640108195