Evidences for the Promising Therapeutic Potential of Boswellia Serrata Against Alzheimer's Disease: Pre-clinical Study
Year: 2014
Type: article
Abstract: Objective: The current study was planned to investigate the anti-inflammatory and antiapoptotic effects of Boswellia serrata methanolic extract against neurodegeneration characterizing Alzheimer’s disease (AD) in rat model. Methods: Adult male Wistar rats were classified into five groups. Group (1) control group; group (2) AD group which was administered orally with AlCl 3 daily for one month; group (3) AD group which was treated orally with rivastigmine daily for three months; group (4) AD group which was treated orally with B. serrata (137.5 mg/kg b. wt) daily for three months and group (5) AD group which was treated orally with B. serrata (68.75 mg/kg b. wt) daily for three months. Brain acetylcholine (Ach), brain and serum acetylcholine (AchE) activity, C-reactive protein (CRP), nuclear factor kappa B (NF-KB), monocyte chemotactic protein-1 (MCP-1), leukotriene B 4 (LTB 4 ) and B-cell lymphoma 2 (Bcl-2) levels were detected. Brain histological investigation of all studied groups was carried out. Results: The data of the current study showed that AlCl 3 administration resulted in significant reduction in brain Ach and brain and serum Bcl-2 levels accompanied with significant elevation in brain and serum AchE, CRP, NF-KB, MCP-1 and LTB 4 levels. Brain histological investigation of rats administered AlCl 3 showed appearance of Aβ plaques characterizing AD. Treatment of rats with B. serrata methanolic extracts caused marked improvement in the measured biochemical parameters as well as in the histological feature of the brain. Conclusion: B. serrata possesses anti-inflammatory and antiapoptotic effect against neuroinflammation characterizing AD.
Institutions: National Research Centre, Tanta University
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1641795243