Early Plasma Soluble Receptor for Advanced Glycation End-Product Levels Are Associated With Bronchiolitis Obliterans Syndrome
Year: 2013
Type: article
Study design: Observational Study
Abstract: Early epithelial injury after lung transplantation may contribute to development of bronchiolitis obliterans syndrome (BOS). We evaluated the relationship between early postoperative soluble receptor for advanced glycation end-product (sRAGE) levels, a marker of type I alveolar cell injury and BOS. We performed a cohort study of 106 lung transplant recipients between 2002 and 2006 at the University of Pennsylvania with follow-up through 2010. Plasma sRAGE was measured 6 and 24 h after transplantation. Cox proportional hazards models were used to evaluate the association between sRAGE and time to BOS, defined according to ISHLT guidelines. Sixty (57%) subjects developed BOS. The average time to BOS was 3.4 years. sRAGE levels measured at 6 h (HR per SD of sRAGE: 1.69, 95% CI: 1.11, 2.57, p = 0.02) and 24 h (HR per SD of sRAGE: 1.74, 95% CI: 1.14, 2.65, p = 0.01) were associated with an increased hazard of BOS. Multivariable Cox regression indicated this relationship was independent of potential confounders. Elevated plasma sRAGE levels measured in the immediate postoperative period are associated with the development of BOS. Early epithelial injury after transplantation may contribute to the development of fibrosis in BOS.
DOI: 10.1111/ajt.12062
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
Awards: G1475688881, Treatment of Pulmonary Edema in Organ Donors, G207824585, Role of anti-Col (V) immunity in primary graft dysfunction, Midcareer Investigator Award in Patient-Oriented Research in Acute Lung Injury, G3422402278, Genetics of primary graft dysfunction, Mentored Patient-Oriented Research in Pulmonary Arterial Hypertension, Clinical Risk Factors for Primary Graft Dysfunction, Lung Transplant donor: prediction, evaluation, and mechanism, Mentored Patient Oriented Research in Lung Transplantation, Biomarker Profiles in the Diagnosis/Prognosis of ARDS, G92921375, G941931125
OpenAlex ID: W1641911126