1,24,25-Trihydroxyvitamin D3
Year: 1973
Type: article
Abstract: A polar metabolite of 24,25-dihydroxyvitamin D3 has been generated both in vivo in rats from 25-hydroxyvitamin D3 and in vitro from 24,25-dihydroxyvitamin D3 with chicken kidney homogenates. This metabolite has been isolated in pure form and identified as 1,24,25-trihydroxyvitamin D3 by means of ultraviolet absorption spectrophotometry, mass spectrometry and its reactivity to periodate treatment. 1,24,25-Trihydroxyvitamin D3 is 60% as active as vitamin D3 in curing rickets. It is less active on a weight basis than 1,25-dihydroxyvitamin D3 in stimulating and sustaining intestinal calcium transport and bone calcium mobilization but appears to have preferential action on the intestine.
Source: Journal of Biological Chemistry
Institution: University of Wisconsin–Madison
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1643395297