Year: 2015
Type: review
Abstract: Obsessive-compulsive disorder (OCD) is a chronic, severe mental illness with up to 2-3% prevalence worldwide. In fact, OCD has been classified as one of the world's 10 leading causes of illness-related disability according to the World Health Organization, largely because of the chronic nature of disabling symptoms.([1]) Despite the severity and high prevalence of this chronic and disabling disorder, there is still relatively limited understanding of its pathophysiology. However, this is now rapidly changing due to development of powerful technologies that can be used to dissect the neural circuits underlying pathologic behaviors. In this article, we describe recent technical advances that have allowed neuroscientists to start identifying the circuits underlying complex repetitive behaviors using animal model systems. In addition, we review current surgical and stimulation-based treatments for OCD that target circuit dysfunction. Finally, we discuss how findings from animal models may be applied in the clinical arena to help inform and refine targeted brain stimulation-based treatment approaches.
Source: Depression and Anxiety
DOI: 10.1002/da.22367
Authors: Susanne E. Ahmari, Darin D. Dougherty
Institutions: University of Pittsburgh, Massachusetts General Hospital
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: bronze
Funders: Burroughs Wellcome Fund, National Alliance for Research on Schizophrenia and Depression, MQ: Transforming Mental Health, National Institutes of Health, Defense Advanced Research Projects Agency, Genentech, National Institute on Aging, National Institute of Mental Health, National Center for Complementary and Alternative Medicine, National Center for Complementary and Integrative Health
Awards: The Neurobiology of Placebo and Nocebo Effects: A Brain Imaging Study, Neurocircuitry Underlying DBS Effects in OCD: A Window Into Mechanisms of Action, G2351926260, Translating OCD gene-association studies into mice to examine SLC1A1 function, G340746905, G3466287845, Neuroimaging Studies of Reward Processing in Depression, G5163636113, Testing the Role of Circuit Plasticity in the Pathology and Treatment of Abnormal, G6114303695, Dissecting Circuits Underlying Obsessive Compulsive Disorder in Humans and Mice, 1/2-CBT Versus Supportive Psychotherapy for Body Dysmorphic Disorder, Aging and the Hypothalamic-Pituitary Reproductive Axis
OpenAlex ID: W1644117706