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Unusual Growth Characteristics of a Methionine-Cyano-B 12 Auxotroph of Escherichia coli

Year: 1967

Type: article

Abstract: Escherichia coli K-12, strain AB1172, substrain 2276, a methionine(-)-cyano-B(12) (-) auxotroph grew poorly when placed in a medium containing optimal levels of cyano-B(12) and suboptimal amounts of l-methionine. A marked depression of N(5,10)-methylene-H(4)-folate reductase was observed in the inhibited cells, although no significant alterations in other enzymes involved in the metabolism of N(5,10)-methylene-H(4)-folate were observed. Guanosine was effective in preventing the growth inhibition.

Source: Journal of Bacteriology

DOI: 10.1128/jb.94.5.1609-1615.1967

Authors: Herbert Dickerman, Robert T. Taylor, Herbert Weissbach

Institution: National Institutes of Health

Language: English

Topic: Folate and B Vitamins Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Zero hunger

Open Access status: green

OpenAlex ID: W1645722049

FWCI:

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Cited by: 1

Related to: 10