Evaluation of the contribution of tannin to the acute pulmonary inflammatory response against inhaled cotton mill dust.
Year: 1988
Type: article
Abstract: Anesthetized, intubated, and mechanically ventilated rabbits were exposed to aerosolized saline, cotton dust extract (CDE), or tannin for 5 minutes and lavaged 4 hours after exposure. Cell numbers and types present in the bronchoalveolar lavage fluid (BALF) were determined and the concentrations of thromboxane A2 (TxA2) and prostaglandin F2-alpha (PGF2-alpha) in the BALF were also analyzed. The saline control animals had increased numbers and percentage of polymorphonuclear leukocytes (PMN) in the BALF as well as increased levels of TxB2 and PGF2-alpha compared with unexposed animals. Exposure to CDE further increased the number and percentage of PMN and the level of PGF2-alpha but had no effect on TxA2 levels when compared with control animals. Tannin exposure increased PGF2-alpha levels to the same extent as CDE exposure. PMN also increased but to a lesser extent than with CDE. These results indicate that the inflammatory response to CDE is only partially due to the tannin present in CDE.
Source: PubMed Central
Authors: D E Lauque, S L Hempel, M A Schroeder, R E Hyatt, M S Rohrbach
Institution: Mayo Clinic
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1652997224