Year: 2013
Type: review
Abstract: The discovery of RNA interference has opened the door for the development of a new class of cancer therapeutics. Small inhibitory RNA oligos are being designed to specifically suppress expression of proteins that are traditionally considered nondruggable, and microRNAs are being evaluated to exert broad control of gene expression for inhibition of tumor growth. Since most naked molecules are not optimized for in vivo applications, the gene silencing agents need to be packaged into delivery vehicles in order to reach the target tissues as their destinations. Thus, the selection of the right delivery vehicles serves as a crucial step in the development of cancer therapeutics. The current review summarizes the status of gene silencing agents in breast cancer and recent development of candidate cancer drugs in clinical trials. Nanotechnology-based delivery vectors for the formulation and packaging of gene silencing agents are also described.
Source: Breast Cancer Research
DOI: 10.1186/bcr3413
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,190
Awards: Targeting Notch, PI3K-AKT and Other Novel Pathways in Breast Cancer Stem Cells, Texas Center for Cancer Nanomedicine, Center for Systematic Modeling of Cancer Development, Development Of Multistage Vectored siRNA Therapeutics For The Treatment Of Breast Cancer, G7112265569, Nanovectors for Characterization and Destruction of Breast Tumor Vasculature, Center for Transport Oncophysics, G8871074205
OpenAlex ID: W1655013267