The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study
Year: 2010
Type: review
Study design: Systematic Review
Abstract: The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene.
Source: Journal of Alzheimer s Disease
Authors: Jean-Charles Lambert, Kristel Sleegers, Antonio González-Pérez, Martin Ingelsson, Gary W. Beecham, Mikko Hiltunen, Onofre Combarros, Maria J. Bullido, Nathalie Brouwers, Karolien Bettens, Claudine Berr, Florence Pasquier, Florence Richard, Steven T. DeKosky, Didier Hannequin, Jonathan L. Haines, Gloria Tognoni, Nathalie Fiévet, Jean-François Dartigues, Christophe Tzourio, Sebastiaan Engelborghs, Beatrice Arosio, Elicer Coto, Peter De Deyn, Maria Del Zompo, Ignacio Mateo, Merce Boada, Carmen Antunez, Jesus Lopez-Arrieta, Jacques Epelbaum, Brit-Maren Michaud Schjeide, Ana Frank-Garcia, Vilmentas Giedraitis, Seppo Helisalmi, Elisa Porcellini, Alberto Pilotto, Paola Forti, Raffaele Ferri, Marc Delepine, Diana Zelenika, Mark Lathrop, Elio Scarpini, Gabriele Siciliano, Vincenzo Solfrizzi, Sandro Sorbi, Gianfranco Spalletta, Giovanni Ravaglia, Fernando Valdivieso, Saila Vepsäläinen, Victoria Alvarez, Paolo Bosco, Michelangelo Mancuso, Francesco Panza, Benedetta Nacmias, Paola Bossù, Olivier Hanon, Paola Piccardi, Giorgio Annoni, David Mann, Philippe Marambaud, Davide Seripa, Daniela Galimberti, Rudolph E Tanzi, Lars Bertram, Corinne Lendon, Lars Lannfelt, Federico Licastro, Dominique Campion, Margaret A. Pericak-Vance, Hilkka Soininen, Christine Van Broeckhoven, Annick Alpérovitch, Agustin Ruiz, M. Ilyas Kamboh, Philippe Amouyel
Institutions: Inserm, Institut Pasteur de Lille, Université Lille Nord de France, University of Antwerp, Institute Born-Bunge, Uppsala University, University of Miami, Kuopio University Hospital, Universidad de Cantabria, Marqués de Valdecilla University Hospital, Consejo Superior de Investigaciones Científicas, Biomedical Research Networking Center on Neurodegenerative Diseases, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Centre Hospitalier Universitaire de Lille, University of Virginia, Vanderbilt University Medical Center, University of Pisa, Université Bordeaux Segalen, Université Pierre-et-Marie-Curie, ZNA Middelheim Hospital, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Hospital Universitario Central de Asturias, University of Cagliari, Fundació ACE, Vall d'Hebron Hospital Universitari, Hospital Universitario Virgen de la Arrixaca, Hospital Universitario La Paz, Université Paris Descartes, Max Planck Institute for Molecular Genetics, University of Bologna, Casa Sollievo della Sofferenza, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, Oasi Maria SS, I.R.C.C.S. Oasi Maria SS, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Fondation Jean Dausset-CEPH, University of Milan, University of Bari Aldo Moro, University of Florence, Fondazione Santa Lucia, University of Milano-Bicocca, University of Manchester, Albert Einstein College of Medicine, Feinstein Institute for Medical Research, Massachusetts General Hospital, QIMR Berghofer Medical Research Institute, University of Pittsburgh
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Sanofi, Fundación Ramón Areces, Institut National de la Santé et de la Recherche Médicale, Academy of Finland, Belgian Federal Science Policy Office, Fondation pour la Recherche Médicale, Fonds Wetenschappelijk Onderzoek, Ministero della Salute, Eisai, Kuopion Yliopistollinen Sairaala, Fondation de France, Università di Pisa, Universiteit Antwerpen, Mutuelle Générale de l'Education Nationale, Vlaamse regering, Instituut Born-Bunge, National Institutes of Health, Bijzonder Onderzoeksfonds UGent, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Awards: G1041122237, G1308196055, G2370712043, G2640555407, G2719705196, G3072246129, Alzheimer's Disease Research Center, G332781187, Revealing Epistasis in Alzheimer Disease, Search for the Alzheimers Genes, Genomic Screen To Identify Alzheimers Disease Genes, An Integrated Genomic Approach to Alzheimer Disease, G931319380
OpenAlex ID: W1657671873