The alpha-subunit of mouse 7 S nerve growth factor is an inactive serine protease.
Year: 1984
Type: article
Abstract: Tryptic and cyanogen bromide peptides accounting for approximately 85% of the amino acid sequence of the alpha-subunit of mouse 7 S nerve growth factor have been isolated and extensively sequenced. The partial structure revealed a high degree of identity with the gamma-subunit (greater than 80%), which is an arginine esteropeptidase of the serine protease family. However, the alpha-subunit does not cleave synthetic arginine ester or peptide substrates nor is it labeled by diisopropylfluorophosphate. The lack of catalytic activity may result from a Gly----His substitution near the active site serine or from the blocked NH2 terminus.
Source: Journal of Biological Chemistry
Authors: P J Isackson, R A Bradshaw
Institution: University of California, Irvine
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1662028436