Work

Coadministration of telaprevir and transcatheter arterial chemoembolization in hepatitis C virus-associated hepatocellular carcinoma

Year: 2013

Type: article

Abstract: The use of direct-acting antiviral agents (e.g., telaprevir, boceprevir) has improved response rates in patients with hepatitis C virus (HCV) genotype 1 infections. Substantial number of drug-drug interactions are anticipated with the use of telaprevir, a cytochrome P450 3A and P-glycoprotein substrate and inhibitor. Herein we describe a patient with HCV-associated hepatocellular carcinoma treated simultaneously with a telaprevir-containing regimen and localized chemotherapy (transcatheter arterial chemoembolization) with doxorubicin. No clinically relevant interactions or adverse events developed while on antiviral therapy.

Source: World Journal of Hepatology

DOI: 10.4254/wjh.v5.i6.332

Authors: Harrys A Torres, Parag Mahale, Ethan D Miller, Thein H Oo, Catherine Frenette, Ahmed O Kaseb

Institutions: The University of Texas MD Anderson Cancer Center, Houston Methodist

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W166535105

FWCI:

Cites: 22

Cited by: 2

Related to: 10