Antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria.
Year: 1975
Type: article
Abstract: This presentation deals with the historical development of the antifolate pyrimidines and related compounds, first as antimalarial substances and later as potent antibacterial agents. It describes the first quantitation of the combined action, through sequential blockade, of the substances with sulfonamides, and outlines the usefulness of the combinations in the therapy of normally sensitive and multiresistant strains of Plasmodium falciparum.
Source: PubMed Central
Author: I M Rollo
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1669885493