Work

Weaning of immunosuppression in long-term recipients of living related renal transplants: a preliminary study.

Year: 1995

Type: article

Abstract: Although renal transplantation continues to be associated with increasingly good short- and long-term graft survival, there remains a need for continued chronic immunosuppression and this can lead to significant complications.1–3 This has prompted the evaluation of withdrawal or modification of immunosuppression by several investigators with varying results.4,5 Emerging data proposing dendritic cell migration and repopulation with chimerism following solid organ transplantation as the basis for graft acceptance have further encouraged evaluation of titrated withdrawal of immunosuppression in select groups of patients.6–8 The finding that donor-specific nonreactivity and chimerism occur simultaneously in long-term living related kidney recipients9 led us to evaluate withdrawal of immunosuppression in these patients.

Source: PubMed