COOH-terminal Amino Acid Sequence of Histidinol Dehydrogenase from a Salmonella typhimurium Mutant
Year: 1972
Type: article
Abstract: A spontaneous prototrophic mutation in the hisD gene of Salmonella typhimurium, hisD2352, alters the COOH-terminal amino acid sequence of the hisD gene product, histidinol dehydrogenase. The wild type sequence, [see PDF for sequence] has been replaced by the sequence -Lys-Ala-Ser-Leu-Thr in the hisD2352 dehydrogenase. The permuted amino acid sequence may be explained if hisD2352 is a two-base deletion near the end of the hisD gene. A unique nucleotide sequence may be written for this region which indicates that the normal termination signal of the hisD gene is UAA or UGA. This single termination codon is followed by a cytosine residue, which constitutes part of an intercistronic region between the hisD and hisC genes.
Source: Journal of Biological Chemistry
Institution: National Institutes of Health
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1673029733