[Extra nuclear localization of steroid receptors and non genomic activation mechanisms].
Year: 2010
Type: article
Abstract: Steroid hormone receptors have been historically considered as nuclear transcription factors. Nevertheless, in the last years, many of them have been detected in the cellular membrane. It has been postulated that their activation can induce transcription independent rapid events involving different second messengers. In addition, several novel steroid hormone receptors, showing a different molecular structure than the classical ones, have also been characterized and most of them are also located in the plasmatic membrane. This review focuses on the variety of effects initiated by glucocorticoids, mineralocorticoids, androgens, estrogens and progesterone, and the possible receptors involved mediating these effects.
Source: PubMed
Authors: María Cecilia Bottino, Claudia Lanari
Language: Spanish
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1674313073