Work

Multipoint interval mapping of quantitative trait loci, using sib pairs.

Year: 1995

Type: article

Abstract: The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.

Source: PubMed Central

Authors: D W Fulker, S S Cherny, L R Cardon

Institution: University of Colorado Boulder

Language: English

Topic: Genetic Mapping and Diversity in Plants and Animals

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute of Mental Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: TRANSITION INTO EARLY ADOLESCENCE, DIFFERENTIAL DIAGNOSIS IN READING DISABILITY, Differential Diagnosis in Learning Disabilities

OpenAlex ID: W1674786313

FWCI: 7.415

Cites: 9

Cited by: 199

Related to: 10