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Co-expression of delta-catenin and RhoA is significantly associated with a malignant lung cancer phenotype.

Year: 2014

Type: article

Abstract: Delta-catenin, a member of the p120-catenin subfamily, and the Rho GTPase RhoA both have roles in the regulation of the cytoskeleton. In this study, we found that delta-catenin positive expression and RhoA over-expression is consistently found in non-small cell lung cancer, but not in normal lung tissue, and that their co-expression was significantly associated with histological type, differentiation, pTNM stage, lymphatic metastasis and a poor prognosis. We also demonstrate that delta-catenin can directly interact with RhoA and regulate its activity, which in turn mediates tumor invasion and metastasis.

Source: PubMed Central

Authors: Di Zhang, Jun-Yi Zhang, Shun-Dong Dai, Shu-Li Liu, Yang Liu, Na Tang, En-Hua Wang

Institution: First Hospital of China Medical University

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1675061342

FWCI: 0.11

Cites:

Cited by: 6

Related to: 10